Table 1.
entry | fluoride source | solvent | T (°C) | time (h) | yieldb (%) |
---|---|---|---|---|---|
1 | TBAF | THF | 0 to rt | 3 | 37 |
2 | TBAF | MeCN | 0 to rt | 3 | 45 |
3 | TBAF | DCM | 0 to rt | 5 | 34 |
4 | CsF | THF | rt | 18 | 37 |
5 | CsF | MeCN | rt | 18 | 76 |
All reactions were carried out on a 0.3 mmol scale in 0.1 M concentration.
Isolated yield.