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. Author manuscript; available in PMC: 2013 Aug 22.
Published in final edited form as: Org Lett. 2008 May 14;10(12):2409–2412. doi: 10.1021/ol800675u

Table 2.

Reaction with Different Benzyne Precursorsa

graphic file with name nihms-489955-t0003.jpg

entry benzyne
precursor
Z product yield
(%)b
1 2b 4,5-Me2 graphic file with name nihms-489955-t0004.jpg 71
2 2c 4,5-
(OMe)2
graphic file with name nihms-489955-t0005.jpg 71
3 2d 4,5-F2 graphic file with name nihms-489955-t0006.jpg 56
4 2e 3-OMe graphic file with name nihms-489955-t0007.jpg 78c
a

All reactions were carried out on a 0.3 mmol scale with 1.2 equiv of benzyne precursor and 2.0 equiv of CsF.

b

Isolated yield.

c

The product was assigned by a 2D-NOESY experiment; see the Supporting Information for details.