Table 2.
entry | benzyne precursor |
Z | product | yield (%)b |
---|---|---|---|---|
1 | 2b | 4,5-Me2 | 71 | |
2 | 2c | 4,5- (OMe)2 |
71 | |
3 | 2d | 4,5-F2 | 56 | |
4 | 2e | 3-OMe | 78c |
All reactions were carried out on a 0.3 mmol scale with 1.2 equiv of benzyne precursor and 2.0 equiv of CsF.
Isolated yield.
The product was assigned by a 2D-NOESY experiment; see the Supporting Information for details.