Table 1.
compound | R | yielda (%) | purityb (%) |
---|---|---|---|
6{1} | 2-ethylphthalimide | 40 | 94 |
6{2} | 2-pyridinyl | 30 | 97 |
6{3} | 1-amino-1-cyclohexyl | 42 | 95 |
6{4} | 4-H2NC6H4 | 62 | 99 |
6{5} | 1-methyl-1H-imidazo-5-yl | 83 | 95 |
6{6} | CH2OH | 67 | 97 |
6{7} | 1-hydroxy-1-cyclohexyl | 59 | 99 |
6{8} | 3-thiophenyl | 75 | 97 |
6{9} | 2-(N-methyl)propyl | 50 | 97 |
6{10} | 4-AcOC6H4 | 60 | 94 |
6{11} | 4-H2NC6H4 | 67 | 93 |
6{12} | 3-O2NC6H4 | 73 | 95 |
6{13} | 4-HO2CC6H4 | 8 | 87 |
Isolated yield after preparative HPLC.
UV purities determined at 214 nm after preparative HPLC.