FIGURE 1.

CRMP2 contains a conserved NDSM consensus motif. A, alignment of a short region of rodent CRMP1–5 sequences with the SUMOylation consensus motif of CRMPs highlighted in yellow. The presence of a negatively charged acidic patch (brown) flanking the canonical motif conforms to the more stringent negatively charged SUMOylation motif (NDSM). The numbers refer to the amino acid residues of rat CRMP2. B, structural representation of CRMP2 (Protein Data Bank code 2GSE (54)) with SUMOylation motif residues identified by yellow spheres (arrow). For clarity, only three monomers of the CRMP2 tetramer are shown.