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. 2013 Jul 10;288(34):24363–24371. doi: 10.1074/jbc.M113.458141

FIGURE 2.

FIGURE 2.

Effect of altering NFκB p50 activity on HCE cell wound healing. A, effect of knocking down NFκB p50 on EGF-induced wound closure. B, significant retardation of wound closure in NFκB p50 knockdown cells in the absence and presence of EGF induction. C, Western blot analysis of NFκB p50 expression in NFκB p50 knockdown cells. D, effect of overexpressing NFκB p50 on EGF-induced wound closure. E, significant acceleration of EGF-induced wound closure in NFκB p50-overexpressed (OE) cells. F, Western blot analysis of NFκB p50 expression in NFκB p50-overexpressed cells. Expression levels of NFκB p50 were altered to be suppressed and enhanced by knocking down HCE cells by knocking down NFκB p50 mRNA and overexpressing full-length cDNA encoding NFκB p50, respectively.