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. 2013 Jul 9;288(34):24656–24665. doi: 10.1074/jbc.M113.453423

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — Influence of GHS-R1a dimerization on arrestin recruitment. A, changes in bimane emission intensity of labeled arrestin 2 induced by GHS-R1a in the presence of increasing concentrations in ghrelin. Data are presented as the percentage of maximum bimane fluorescence change measured in the presence of ghrelin. B, changes in emission intensity of bimane-labeled arrestin 2 induced by the purified receptors in the absence and presence of ligands (full agonist, ghrelin; partial agonist, JMV3002; neutral antagonist, JMV3011; inverse agonist, SPA; ligand concentration, 10 μm). 1a, GHS-R1a monomer; 1b, GHS-R1b monomer; 1a:1a, GHS-R1a-GHS-R1a homodimer; 1a:1b, GHS-R1a-GHS-R1b dimer. In all cases, data are presented as the mean ± S.D. from three independent experiments.