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. 2013 Aug 23;5:5. doi: 10.3389/fnsyn.2013.00005

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Copyright © 2013 Aksoy-Aksel and Manahan-Vaughan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The paired-pulse ratio is different for pp-CA1 and Sc-CA1 synapse depending on stimulus intensity. (A) Left: Paired-pulse ratio profiles for pp-CA1 and Sc-CA1 synapses at low-intensity stimulation (corresponding to the intensity necessary to evoke 40% of the maximum). Right: Example of fEPSPs evoked from corresponding synapse and interstimulus interval (Vertical scale bar: 4 mV, horizontal scale bar: 5 ms for all) (B) Left: Paired-pulse ratio profiles for pp-CA1 synapses and for the Sc-CA1 synapses at high-intensity levels (double the low-intensity or maximum of 400 μA). Increasing the stimulation intensity did not result in a significant change for the pp-CA1 synapse but led to paired-pulse depression at all interstimulus intervals for the Sc-CA1 synapse. The paired-pulse intervals used were: 20, 25, 40, 50, and 100 ms for both groups. All the recordings were collected from awake unrestrained but stationary animals. ^*indicates p < 0.05 (Student's t-test). Right: Example of fEPSPs evoked from corresponding synapse and interstimulus interval (Vertical scale bar: 4 mV, horizontal scale bar: 5 ms).