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Bacterial outgrowth in blood, spleen, lung brain and CSF. Bacterial titers in WT vs., Nlrp3−/− mice at 6 (A) and 30 hours (B); and WT vs. and Asc−/− mice at 6 (C) and 30 hours (D) after induction of pneumococcal meningitis. Twelve mice per group were analyzed. Data are given as medians and 75th quartile. * P < 0.05.
