Table 5.
Derived pharmacophore model for antibacterial activity of acridones against M. luteus
| Acridones | Score obtained | Categorizing through threshold (S = 4.1466) | Predicted activity | Experimental activity (MIC in μg/mL) | Experimental response |
|---|---|---|---|---|---|
|
1. |
4.668387 |
>4.1466 |
significantly active |
>500 |
Non active |
|
2. |
4.655514 |
>4.1466 |
significantly active |
Not tested |
Not tested |
|
3. |
4.409138 |
>4.1466 |
significantly active |
125 |
Active |
|
4. |
5.006913 |
>4.1466 |
significantly active |
125 |
Active |
|
5. |
3.892896 |
<4.1466 |
Non-significant activity |
Not tested |
Not tested |
|
6. |
4.049106 |
<4.1466 |
Non-significant activity |
Not tested |
Not tested |
|
7. |
2.944231 |
<4.1466 |
Non-significant activity |
500 |
Less active |
|
8. |
4.008224 |
<4.1466 |
Non-significant activity |
>500 |
Non active |
|
9. |
4.189883 |
>4.1466 |
significantly active |
Not tested |
Not tested |
| 10. | 4.479721 | >4.1466 | significantly active | >500 | Not active |
The threshold score (S) of 4.1466 has been selected for the screening of lead compounds.