Table 9.
Compliance of acridone alkaloids with standard parameters of Lipinski’s rule of five for drug likeness and oral bioavailability
| Acridone alkaloids | miLOGP | MW | nON | nOHNH | nviolations |
|---|---|---|---|---|---|
|
1 |
1.926 |
301.298 |
6 |
2 |
0 |
|
2 |
1.862 |
257.245 |
5 |
3 |
0 |
|
3 |
1.119 |
303.27 |
7 |
4 |
0 |
|
4 |
2.189 |
285.299 |
5 |
1 |
0 |
|
5 |
2.433 |
255.273 |
4 |
1 |
0 |
|
6 |
1.913 |
271.272 |
5 |
2 |
0 |
|
7 |
2.173 |
255.273 |
4 |
1 |
0 |
|
8 |
2.476 |
355.39 |
6 |
2 |
0 |
|
9 |
2.2 |
341.363 |
6 |
3 |
0 |
| 10 | 2.411 | 357.362 | 7 | 3 | 0 |
miLogP = octanol/water partition coefficient, MW = molecular weight, nON = number of hydrogen acceptor, nOHNH = number of hydrogen donor, nviolations = violations from Lipinski’s rule.