Table 1.
Characteristics of severe and non-severe leukopenia in a French cohort of 148 patients with S. aureus-necrotizing pneumonia, between 1986 and 2010
|
Variables |
Group 1 |
Group 2 |
P value |
|---|---|---|---|
| (≤3.000 leukocytes/mL) n=62 | (>3 000 leukocytes/mL) n=86 | ||
|
Demographic information |
|
|
|
|
Age |
|
|
|
| 0-30 |
32 (51.6) |
55 (64.0) |
0.132 |
| >30 |
30 (48.4) |
31 (36.0) |
|
| Gender, M:F (ratio) |
29:33 (46.8) |
59:27 (68.6) |
0.008 |
|
Medical history |
|
|
|
| Smoking |
7 (12.5) |
16 (19.5) |
0.278 |
| Alcohol |
1 (1.7) |
3 (3.7) |
0.479 |
| Steroid treatment |
2 (3.3) |
7 (8.3) |
0.222 |
| Respiratory failure |
0 (0) |
3 (3.5) |
0.138 |
| Personal history of furuncles or skin abscess |
1 (2.0) |
12 (16.0) |
0.011 |
|
Before hospital admission | |||
| Period between onset of symptoms and admissiona |
3 (2-4) |
3 (2-5) |
0.684 |
| Influenza-like illness |
46 (79.3) |
41(49.4) |
<0.001 |
| SSTIb |
6 (9.7) |
27 (31.4) |
0.002 |
|
Clinical features within the first 48 h of hospitalization |
|
||
| PRISM scorea, b |
27 (20-35) |
6 (4-11) |
<0.001 |
| SAPS II scorea, b |
67 (39-80) |
28 (15-61.8) |
<0.001 |
| Platelet count/mL |
92,000 (46,500-176,500) |
204,000 (145,000-370,000) |
<0.001 |
| Fever, temperature >39°C |
46 (64.2) |
70 (81.4) |
0.294 |
| Generalized rash 24 h |
5 (8.3) |
6(7.0) |
0.760 |
| Airway hemorrhage |
39 (62.9) |
20 (23.3) |
<0.001 |
| Pleural effusion |
16 (27.1) |
49 (57.6) |
<0.001 |
| Radiological consolidation |
|
|
0.001 |
| Unilobar |
6 (9.8) |
30 (34.9) |
|
| Multilobar |
48 (78.7) |
44 (51.2) |
|
| ARDSb |
47 (77.0) |
15 (18.1) |
<0.001 |
| Methicillin resistance (mecAgene) |
15 (24.2) |
20 (23.3) |
0.895 |
|
Treatment and outcome | |||
| Mechanical ventilation |
57 (91.9) |
37 (43.0) |
<0.001 |
| Inotrope drugs |
52 (91.2) |
21 (26.3) |
<0.001 |
| Time to deatha |
2 (1-6) |
2 (1-2.75) |
0.216 |
| Appropriate antibiotics introduced in first 24 h of h hospitalization |
46 (75.4) |
65 (75.6) |
0.161 |
| Mortality |
47 (75.8) |
14 (16.3) |
<0.001 |
| Percentage of deaths attributed to S. aureus infection | 47 (100) | 13 (92.9) | 0.065 |
aContinuous variables are indicated as median, first and third quartiles and categorical variables as number (%).
bSSTI: skin and soft tissue infection, PRISM: Pediatric Risk of Mortality; SAPS II: Simplified Acute Physiology Score; ARDS: acute respiratory distress syndrome.