Table 3.

HbA_1c-values and measures of HbA_1c-variability

Variable	n (%)	Current HbA1c, %	HbA1c-MEAN, %	HbA1c-SD, %	HbA1c-CV, %	Adj-HbA1c-SD, %
No CVD	6,157 (74.3)	7.57±1.36	7.63±1.19	0.59±0.48	7.57±5.52	0.52±0.42
		7.42 (6.70-8.28)	7.49 (6.81-8.31)	0.46 (0.28-0.73)	6.06 (3.94-9.37)	0.40 (0.26-0.67)
Any coronary event	1,373 (16.6)	7.85±1.34	7.88±1.20	0.60±0.45	7.40±5.13	0.53±0.39
		7.70 (6.92-8.57)	7.77 (7.02-8.59)	0.47 (0.29-0.74)	6.18 (3.95-9.22)	0.41 (0.26-0.66)
P		<0.0001	<0.0001	0.194	0.821	0.140
Acute myocardial infarction	949 (11.4)	7.80±1.31	7.86±1.18	0.62±0.45	7.64±5.08	0.54±0.39
		7.67 (6.92-8.51)	7.78 (7.05-8.53)	0.49 (0.31-0.77)	6.39 (4.13-9.44)	0.43 (0.27-0.67)
P		<0.0001	<0.0001	0.004	0.068	0.003
Any cerebrovascular event	902 (10.9)	8,00±1.51	7.96±1.24	0.59±0.45	7.18±4.91	0.52±0.40
		7.75 (7.02-8.73)	7.83 (7.12-8.64)	0.47 (0.28-0.72)	5.91 (3.74-8.92)	0.41 (0.25-0.64)
P		<0.0001	<0.0001	0.956	0.103	0.672
Stroke	257 (3.1)	7.64±1.37	7.70±1.21	0.59±0.40	7.56±4.86	0.51±0.34
		7.45 (6.61-8.43)	7.63 (6.75-8.45)	0.48 (0.30-0.74)	6.28 (4.25-9.40)	0.42 (0.27-0.64)
P		0.470	0.354	0.299	0.381	0.325
Any lower limb vascular event	584 (7.0)	8.02±1.45	8.02±1.19	0.64±0.50	7.68±5.34	0.56±0.45
		7.85 (7.09-8.73)	7.92 (7.22-8.66)	0.50 (0.31-0.80)	6.32 (4.10-9.38)	0.45 (0.27-0.69)
P		<0.0001	<0.0001	0.013	0.372	0.005
Ulceration/gangrene	319 (3.8)	7.93±1.55	8.01±1.25	0.71±0.58	8.49±5.93	0.62±0.51
		7.67 (6.98-8.62)	7.88 (7.18-8.64)	0.54 (0.34-0.86)	6.76 (4.31-10.23)	0.48 (0.30-0.76)
P		<0.0001	<0.0001	<0.0001	0.004	<0.0001

Current HbA_1c, HbA_1c-MEAN, HbA_1c-SD, HbA_1c-CV, and Adj-HbA_1c-SD values in patients with any major acute CVD event by vascular bed (coronary, carotid and lower limb) versus subjects without CVD. Values are mean±SD and median (interquartile range); P values for comparison between groups using the Student’s t test for parametric or the corresponding Mann–Whitney U test for nonparametric (HbA_1c-SD, HbA_1c-CV, and Adj- HbA_1c-SD) variables.