Table 4.
Independent correlates of any CVD event(s)
Variables |
Any CVD event |
||
---|---|---|---|
OR | 95%CI | P | |
Age, x year |
1.018 |
1.011-1.024 |
<0.0001 |
Diabetes duration, x year |
1.019 |
1.013-1.025 |
<0.0001 |
Gender, male |
1.746 |
1.550-1.967 |
<0.0001 |
BMI, x unit |
- |
- |
- |
Smoking |
|
|
<0.0001 |
No |
1.0 |
|
|
Former |
1.413 |
1.254-1.591 |
<0.0001 |
Current |
1.156 |
0.986-1.354 |
0.074 |
Triglycerides, x 0.0113 mmol/l |
0.999 |
0.999-1.000 |
0.040 |
HDL cholesterol, x0.259mmol/l |
0.983 |
0.978-0.987 |
<0.0001 |
Dyslipidemia |
1.713 |
1.470-1.997 |
<0.0001 |
Hypertension |
2.054 |
1.699-2.484 |
<0.0001 |
Diabetes treatment, n (%) |
|
|
<0.0001 |
Diet |
1.0 |
|
|
OHA |
1.266 |
1.038-1.544 |
0.020 |
Insulin + OHA |
1.228 |
0.942-1.601 |
0.128 |
Insulin |
2.051 |
1.623-2.593 |
<0.0001 |
Albuminuria |
|
|
0.052 |
Normoalbuminuria |
1.0 |
|
|
Microalbuminuria |
1.167 |
1.030-1.323 |
0.015 |
Macroalbuminuria |
1.069 |
0.845-1.351 |
0.580 |
eGFR (MDRD) |
|
|
<0.0001 |
≥90 ml/min/1.73 m2 |
1.0 |
|
|
60–89 ml/min/1.73 m2 |
1.116 |
0.975-1.278 |
0.112 |
30–59 ml/min/1.73 m2 |
1.820 |
1.531-2.162 |
<0.0001 |
<30 ml/min/1.73 m2 |
2.278 |
1.541-3.367 |
<0.0001 |
Retinopathy |
|
|
<0.0001 |
No retinopathy |
1.0 |
|
|
Non advanced retinopathy |
1.295 |
1.122-1.495 |
0.0001 |
Advanced retinopathy |
1.298 |
1.084-1.554 |
0.005 |
MODEL 1 |
|
|
|
HbA1c-MEAN, 1% increment |
1.062 |
1.011-1.114 |
0.016 |
MODEL 2 |
|
|
|
HbA1c-MEAN, 1% increment |
1.062 |
1.011-1.114 |
0.016 |
HbA1c-SD, 1% increment |
- |
- |
- |
MODEL 3 |
|
|
|
HbA1c-MEAN |
|
|
0.001 |
quartile 1 |
1.0 |
|
|
quartile 2 |
0.923 |
0.787-1.082 |
0.322 |
quartile 3 |
1.248 |
1.066-1.462 |
0.006 |
quartile 4 |
1.096 |
0.928-1.295 |
0.281 |
HbA1c-SD quartiles | – | – | – |
Logistic regression analysis with backward variables selection of independent correlates of any CVD event versus no CVD event. ORs of variables except HbA1c-MEAN, HbA1c-SD, and their quartiles were determined by multivariate logistic analysis from MODEL 1. The results did not change significantly in MODEL 2 and MODEL 3.