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. 2013 Aug 9;11:91. doi: 10.1186/1741-7007-11-91

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Copyright © 2013 Manov et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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3MCA-induced tumor in Spalax. (A) Light microscopic examination. Note spindle, epithelioid and giant multinuclear cells (empty arrow); nuclei are variable in shape, size and chromatin distribution; nucleoli vary in frequency. Hematoxylin and eosin staining, ×100. (B) Transmission electron microscopy (TEM): dilated, elongated rough endoplasmic reticulum (black arrows) and abundant collagen fibers (white arrows) (C) TEM: a giant, monstrous nucleus (N). (D) Cell line established from Spalax tumor, phase contrast image after six months of continuous cultivation (×200). 3MCA, 3-Methylcholantrene.