Table 4.
Pathway-specific transcription factor profile
|
A. p38-related TF* profile by cluster | |||||
|---|---|---|---|---|---|
| Cluster | 1 | 2 | 3 | 4 | 5 |
| Transcription |
NF-κB |
|
|
|
NF-κB |
| Factors |
SPI-1 |
|
SPI-1 |
|
SPI-1 |
| |
|
ATF2 |
ATF2 |
ATF2 |
|
| |
|
CREB1 |
CREB1 |
|
CREB1 |
| |
|
|
|
ELK-1 |
ELK-1 |
| |
|
|
JUN |
JUN |
|
|
B. Cluster-specific TF pathway profiles | |||||
|
Cluster |
2 |
3 |
4 |
7 |
|
|
Pathway Membership |
TLR4 |
Wnt, E2F |
Apoptosis |
STAT binding |
|
| Transcription |
IRF3, 7 |
|
|
|
|
| Factors |
|
ETF2 |
|
|
|
| |
|
LEF1/TCF7 |
|
|
|
| |
|
|
FOXO3, 4 |
|
|
| |
|
|
ELK-1 |
|
|
| |
|
|
MYC |
|
|
| STAT1, 3, 5A | |||||
*TF Transcription factors predicted by BIOBASE [43] to bind cluster members as defined in the text.