Figure 4b:

(a) Representative maximum intensity projection shows enhancement of tumor (arrow, left image) vasculature after injection of biotin-bovine serum albumin gadopentetate dimeglumine, which enabled measurement of fBV in tumor. Map of fBV for one section in the tumor (right) shows elevated fBV around highly angiogenic tumor rim (arrows), and depressed fBV at core of tumor. (b) Mean fBV was similar in control, FHC, and FHC-FC tumors, which shows that overexpression of FHC in cancer-associated fibroblasts does not alter vascularity of maturing tumor.