Table 4.
Changes of laboratory and echocardiographic parameters during the follow-up period
| Parameter | Baseline | After 18 months ± 5 | After 36 months ± 10 | p value for Baseline vs. 18 months assessment | p value for 18 months assessment vs. 36 months assessment | p value for Baseline vs. 36 assessment |
|---|---|---|---|---|---|---|
|
eGFR (MDRD) (ml/s) |
0.6 |
0.57 |
0.49 |
p < 0.01 |
p < 0.05 |
p < 0.01 |
| (0.25-1.6) |
(0.25-1.3) |
(0.26-2.8) |
|
|
|
|
|
Haemoglobin (g/l) |
128.5 ± 20.0 |
128.8 ± 20.7 |
124.3 ± 18.8 |
p < 0.01 |
p < 0.01 |
NS |
|
Serum Phosphate (mmol/l) |
1.10 |
1.16 |
1.20 |
NS |
NS |
NS |
| (1.00-1.29) |
(1.00-1.45) |
(1.00-1.36) |
|
|
|
|
|
Parathyroid hormone (pg/ml) |
5.96 |
6.34 |
7.52 |
NS |
NS |
NS |
| (3.56-9.22) |
(4.56-11.98) |
(3.63-15.59) |
|
|
|
|
|
25OH Vitamin D (ng/ml) |
23.47 ±8.91 |
25.04 ±9.61 |
20.87 ±7.79 |
NS |
p < 0.01 |
p < 0.02 |
|
FGF23 (RU/ml) |
89.6 |
100.1 |
127.0 |
p < 0.01 |
p < 0.05 |
p < 0.0001 |
| (64.8-167.1) |
(73.0-228.8) |
(78.3-282.4) |
|
|
|
|
|
PAPP-A (mIU/l) |
8.3 |
8.7 |
9.3 |
NS |
NS |
NS |
| (7.0-10.2) |
(7.6-10.5) |
(7.5-12.6) |
|
|
|
|
|
sRAGE (pg/ml) |
976.3 |
919.1 |
1040.7 |
NS |
NS |
NS |
| (720.6-1495.2) |
(643.9-1336.3) |
(719.1-1375.1) |
|
|
|
|
|
EN-RAGE (ng/ml) |
160.5 |
255.2 |
269.8 |
p < 0.05 |
NS |
p < 0.001 |
| (100.5-240.3) |
(164.6-297.0) |
(163.0-326.3) |
|
|
|
|
|
PlGF (pg/ml) |
10.80 |
11.05 |
12.5 |
p < 0.02 |
NS |
NS |
| (7.8-14.2) |
(8.5-15.6) |
(8.5-14.7) |
|
|
|
|
|
MMP-2 (ng/ml) |
214.5 ±50.6 |
206.5 ±39.2 |
221.9 ±61.6 |
NS |
NS |
NS |
|
Troponin I (ng/ml) |
0.01 |
0.01 |
0.01 |
NS |
NS |
NS |
| (0.01-0.01) |
(0.01-0.01) |
(0.01-0.01) |
|
|
|
|
|
BNP (pg/ml) |
30.0 |
57.0 |
77.0 |
p < 0.01 |
NS |
p < 0.0001 |
| (15.0-91.0) |
(27.8-107.3) |
(40.0-195.0) |
|
|
|
|
|
Left ventricle mass index (g/m2.7) |
43.6 ± 14.6 |
45.3 ± 16.0 |
45.7 ± 13.4 |
NS |
NS |
p < 0.05 |
|
Left ventricle EF (%) |
64.7 ± 7.8 |
64.5 ± 5.8 |
62.7 ± 8.0 |
p < 0.05 |
NS |
p < 0.05 |
|
Left atrial diameter (cm/m2) |
2.14 ± 0.64 |
2.05 ± 0.55 |
2.19 ± 0.50 |
NS |
NS |
p < 0.01 |
|
E/A ratio |
0.83 |
0.83 |
0.81 |
NS |
NS |
NS |
| (0.67 - 1.14) | (0.69 - 0.98) | (0.72-1.04) |
Arithmetic mean ± SD or median (Interquartile Range).
Comparison: Paired samples t-test for normal distributions, resp. Wilcoxon test for skewed distrubutions.
Abbreviations: BNP brain natriuretic peptide, BSA body surface area, E/A ratio Ratio between early (E) and late (atrial - A) ventricular filling velocity eGFR: estimated glomerular filtration rate, EN-RAGE Extracellular newly identified RAGE-binding protein, FGF23 fibroblast growth factor 23, MDRD modification of diet in renal disease, MMP-2 matrix-metaloproteinase 2, PAPP-A pregnancy associated protein A, PlGF placental growth factor.