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. 2013 Aug 5;14:40. doi: 10.1186/2050-6511-14-40

Table 2.

Parameter estimates of the anakinra effect on c-reactive protein concentrations in 22 SJIA patients (RESP = responders and RESI = patients with onset of “resistance” to treatment)

Parameter Estimate Relative standard error (%)
Baseline (mg/L)
 
 
 RESP
141
27
 RESI
37.9
29
kTR (day-1)
0.042
27
C50 (mg/L)
0.03
37
kRESI (day-1)
0.0048
0.0018
Proportion of RESP
0.37
31
ηBASELINE.RESI
0.79
24
ηKTR
081
25
ϵ, mg/L (*) 0.39 6

Key: Baseline, CRP level before treatment; kTR, transit time rate constant; C50, anakinra concentration that induces a 50% decrease of CRP level; kRESI, time rate constant of resistance appearance; η, between-subject variability; ϵ, constant residual variability, *log-additive model.