Table 2.
Parameter | Estimate | Relative standard error (%) |
---|---|---|
Baseline (mg/L) |
|
|
RESP |
141 |
27 |
RESI |
37.9 |
29 |
kTR (day-1) |
0.042 |
27 |
C50 (mg/L) |
0.03 |
37 |
kRESI (day-1) |
0.0048 |
0.0018 |
Proportion of RESP |
0.37 |
31 |
ηBASELINE.RESI |
0.79 |
24 |
ηKTR |
081 |
25 |
ϵ, mg/L (*) | 0.39 | 6 |
Key: Baseline, CRP level before treatment; kTR, transit time rate constant; C50, anakinra concentration that induces a 50% decrease of CRP level; kRESI, time rate constant of resistance appearance; η, between-subject variability; ϵ, constant residual variability, *log-additive model.