Figure 8.

Pedigree of the lissencephaly and cerebellar hypoplasia affected Churra sheep. The pattern is compatible with an autosomal recessive inheritance model. The pedigree relationships were confirmed using 19 microsatellite markers. Symbols used in the pedigree are those proposed in humans by the “Pedigree Standardization Work Group of the National Society of Genetic Counselors” [23]. Briefly, square represent male, circle female, shaded square-affected male, shaded circle-affected female. A diamond for the individual symbol is used to indicate animals with gender not specified (males and females). Numbers inside the symbol represent multiple individuals.