Table 1.
Involvement of selected DUBs in the regulation of cancer-related signalling pathways and cellular processes
| DUB | Signalling pathway/Process | Substrate |
|---|---|---|
| USP2a |
Fas and p53 |
FAS, MDM2, MDMX |
| Mitotic progression |
Aurora A |
|
| NF-κB |
RIP1, TRAF2, TRAF6 |
|
| Cell cycle |
Cyclin A1 |
|
| USP4 |
Wnt |
TCF4 |
| p53 |
ARF-BP1 |
|
| NF-κB |
TAK1, TRAF2, TRAF6, RIP1 |
|
| TGF-β and AKT |
TβRI |
|
| Growth factor receptor pathways |
PDK1 |
|
| USP7 |
p53 |
p53, MDM2, MDMX |
| Akt |
FOXO4, PTEN |
|
| USP10 |
Transcriptional regulation |
H2A.Z |
| p53 |
p53 |
|
| USP29 |
p53 |
p53 |
| USP42 |
p53 |
p53 |
| USP8/Ubpy |
Endosomal sorting |
EGFR |
| Wg/Wnt |
Frizzled |
|
| Hedgehog |
Smoothened |
|
| AMSH |
Endosomal sorting |
EGFR |
| Cezanne |
NF-κB |
TRAF6, RIP1 |
| CYLD | NF-κB | TRAF2, TRAF6, TRAF7, TAK1, RIP1 |
Table shows several human DUBs involved in the regulation of different signalling pathways/processes, as well as their reported substrates. An extended version of this Table, including references, is provided as Additional file 1: Table S1.