Table 3.
Distribution of genotype and allele frequencies of IL1B SNP
|
Gene |
4 statistical models |
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
IL1B |
|
Controls |
Cases |
Multiplicative |
Additive |
Dominant |
Recessive |
||||
| SNP ID | Genotype | No (%) | No (%) | P value | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) |
| rs1143623 |
GG |
57 (29.7) |
37 (22.2) |
0.106 |
1.27 (0.95-1.71) |
|
|
0.105 |
1.48 (0.92-2.40) |
0.318 |
1.28 (0.79-2.07) |
| GC |
92 (47.9) |
85 (50.9) |
|
|
0.633 |
1.13 (0.68-1.89) |
|
|
|
|
|
| CC |
43 (22.4) |
45 (26.9) |
|
|
0.11 |
1.61 (0.90-2.90) |
|
|
|
|
|
| rs3917345 |
DEL/DEL |
191 (99.5) |
166 (99.4) |
0.541 |
1.15 (0.07-18.47) |
|
|
0.541 |
1.15 (0.07-18.55) |
— |
— |
| DEL/TGGT |
1 (0.5) |
1 (0.6) |
|
|
— |
— |
|
|
|
|
|
| TGGT/TGGT |
0 (0.0) |
0 (0.0) |
|
|
— |
— |
|
|
|
|
|
| rs1143627 | TT |
84 (43.8) |
47 (28.1) |
0.002 |
1.62 (1.20-2.18) |
|
|
0.002 |
1.99 (1.28-3.09) |
0.063 |
1.68 (0.97-2.91) |
| TC |
81 (42.2) |
84 (50.3) |
|
|
0.399 |
1.29 (0.72-2.31) |
|
|
|
|
|
| CC | 27(14.1) | 36 (21.6) | 0.005 | 2.38 (1.29-4.40) | |||||||
CI, confidence interval; OR, odds ratio. The P values <0.05 were emphasized in boldface.