Table 5.
Cox proportional univariate and multivariate analyses of the association between prognostic variables and overall survival in cervical cancer
| |
Univariate analysis |
Multivariate analysis based on HIF-1αa |
Multivariate analysis based on c-Meta |
|||
|---|---|---|---|---|---|---|
| Hazard ratio [95% CI] | p value | Hazard ratio [95% CI] | p value | Hazard ratio[95% CI] | p value | |
|
FIGO stage (≥IIb) |
2.60 [1.02-6.56] |
0.043 |
1.03 [0.31-3.40] |
0.951 |
0.96 [0.28-3.25] |
0.951 |
|
Tumor grade (poor) |
1.39 [0.55-3.51] |
0.486 |
NA |
|
NA |
|
|
Tumor size (> 4 cm) |
2.33 [0.91-5.94] |
0.076 |
NA |
|
NA |
|
|
LVSI |
2.81 [0.99-7.94] |
0.050 |
0.91 [0.19-4.35] |
0.915 |
0.79 [0.17-3.59] |
0.768 |
|
LN metastasis |
4.96 [1.75-13.99] |
0.008 |
4.23 [0.84-21.34] |
0.080 |
4.83 [1.09-21.42] |
0.038 |
|
HIF-1αb |
2.91 [1.09-7.78] |
0.019 |
1.84 [0.54-6.30] |
0.326 |
NA |
|
| c-Metc | 1.96 [1.22-3.16] | 0.005 | NA | 3.27 [1.05-10.23] | 0.041 | |
NA, not applicable; LVSI, lymphovascular space invasion; a Separate multivariate analysis for HIF-1α and c-MET was performed because both factors are dependent on each other, b Cut-off value of HIF-1α is 8 of IHC score, c Cut-off value of c-Met is 8 of IHC score.