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. 2013 May 7;4(8):1204–1216. doi: 10.1021/cn4000583

Figure 3.

Figure 3

Leu-enkephalin and compounds 1–8 activate ERK1/2. Following agonist stimulation of DOPr, ERK1/2 proteins are rapidly and transiently phosphorylated (activated). (A) Western blot of ERK1/2 phosphorylation (pERK1 and pERK2) after 5 min of stimulation of DRGF11/DOPr-GFP cells with increasing concentrations (10–9–10–5 M) of Leu-enkephalin. (B) Densitometric analyses of Western blot results (pERK compared to control) obtained with increasing concentrations of Leu-enkephalin and compounds 1–8.