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Leu-enkephalin and compounds 4 and 8 induce DOPr internalization. Stimulation of DOPr with an agonist rapidly induces its internalization. Micrographs were taken before (control) and 30 min after treatment of DRGF11/DOPr-GFP cells with 1 μM of Leu-enkephalin or compound 4 or 8. All compounds induced robust internalization of DOPr. Indeed, while the membrane labeling is decreased, fluorescent vesicle-like structures are clearly visible inside the cells stimulated with the agonists.
