Table 1.
Pathway analysis of transcripts significantly altered in mammary tissue by GLY and SOY diets relative to the control C/L diet.
| Pathway | list | # ↑ | # ↓ | geneset | z-score ↑ | z-score ↓ |
|---|---|---|---|---|---|---|
| GLY (z-score > 2) | ||||||
|
|
||||||
| Glycerophospholipid metabolism | 5 | 5 | 0 | 67 | 5.17 | -0.38 |
| Glycerolipid metabolism | 4 | 4 | 0 | 41 | 5.47 | -0.29 |
| Metabolism of xenobiotics by cytochrome P450 | 4 | 4 | 0 | 59 | 4.33 | -0.35 |
| ECM-receptor interaction | 4 | 3 | 1 | 76 | 2.49 | 2.15 |
| Malaria | 3 | 3 | 0 | 48 | 3.54 | -0.32 |
| Drug metabolism - cytochrome P450 | 3 | 3 | 0 | 57 | 3.13 | -0.35 |
| PPAR signaling pathway | 3 | 3 | 0 | 58 | 3.09 | -0.35 |
| SOY (z-score > 2) | ||||||
|
|
||||||
| ECM-receptor interaction | 4 | 3 | 1 | 76 | 5.01 | 3.12 |
| Malaria | 4 | 3 | 1 | 48 | 6.54 | 4.05 |
| Focal adhesion | 4 | 3 | 1 | 184 | 2.75 | 1.75 |
| Hypertrophic cardiomyopathy | 3 | 3 | 0 | 76 | 5.01 | -0.30 |
| Dilated cardiomyopathy | 3 | 3 | 0 | 82 | 4.79 | -0.31 |
Pathways were identified by KEGG analysis from gene probes with FC > 1.5, P < 0.05, and at least 3 genes altered in the same direction within a pathway. Only pathways with significant z-score (> 2) are shown.