Table 2.
Clinical features of uterine cancer (all ages)
| Feature | Cases, n (%), n = 2732 | Controls, n (%), n = 9537 | LR (95% CI) | OR in multivariate analysis (95% CI) |
|---|---|---|---|---|
| Symptoms | ||||
| Postmenopausal bleeding, one visit to GPa | 926 (33.9) | 53 (0.6) | 61.0 (46.4 to 80.2) | 154.5 (100.4 to 237.8) |
| Postmenopausal bleeding, two or more visits to GPa | 349 (12.8) | 7 (0.1) | 174.0 (82.5 to 367.3) | 578.9 (187.0 to 1792.1) |
| Excessive bleeding | 109 (4.0) | 35 (0.4) | 10.9 (7.5 to 15.9) | 22.28 (11.86 to 41.84) |
| Irregular menstruation, one visit to GPa | 426 (15.6) | 43 (0.5) | 34.6 (25.4 to 47.2) | 41.50 (27.31 to 63.05) |
| Irregular menstruation, two visits to GPa | 154 (5.6) | 11 (0.1) | 48.9 (26.6 to 90.0) | 69.04 (31.62 to 150.72) |
| Vaginal discharge | 204 (7.5) | 65 (0.7) | 11.0 (8.31 to 14.4) | 13.75 (9.98 to 21.04) |
| Haematuria | 120 (4.4) | 51 (0.5) | 8.21 (5.94 to 11.37) | 8.71 (5.03 to 15.06) |
| Abdominal pain, one visit to GPa | 138 (5.1) | 306 (3.2) | 1.57 (1.29 to 1.92) | 1.97 (1.40 to 2.76) |
| Abdominal pain, two visits to GPa | 64 (2.3) | 95 (1.0) | 2.35 (1.72 to 3.22) | 3.41 (1.99 to 5.83) |
|
| ||||
| Investigations | ||||
| Low haemoglobin | 202 (7.4) | 398 (4.2) | 1.77 (1.50 to 2.09) | 2.12 (1.53 to 2.94) |
| Raised platelets | 110 (4.0) | 207 (2.2) | 1.86 (1.48 to 2.33) | 1.50 (1.00 to 2.25) |
| Raised glucose | 316 (11.6) | 673 (7.1) | 1.64 (1.44 to 1.86) | 1.37 (1.06 to 1.77) |
LR = likelihood ratio. OR = odds ratio.
a
The ORs presented for the first or second time a symptom is reported to the GP compares to a patient who has not reported the presence of a symptom to their GP. All associations in the model have P<0.001, other than raised platelets, P = 0.049 and raised glucose, P = 0.016.