Table 2.
Strong inducers or inhibitors of CYP (cytochrome P450) enzymes[19]
|
INHIBITORS | |||
|---|---|---|---|
| 1A2 | 2B6 | 2C8 | 2C19 |
| Cimetidine |
Thiotepa |
Gemfibrozil |
Fluoxetine |
| Fluoroquinolones |
Ticlopidine |
Montelukast |
Fluvoxamine |
| Fluvoxamine |
|
|
Ketoconazole |
| Ticlopidine |
|
|
Lansoprazole |
| |
|
|
Omeprazole |
| |
|
|
Ticlopidine |
|
INHIBITORS | |||
|
2C9 |
2D6 |
2E1 |
3A4,5,7 |
| Amiodarone |
Amiodarone |
Disulfiram |
HIV antivirals: |
| Fluconazole |
Bupropion |
|
Indinavir |
| Isoniazid |
Chlorpheniramine |
|
Nelfinavir |
| |
Cimetidine |
|
Ritonavir |
| |
Clomipramine |
|
Amiodarone |
| |
Duloxetine |
|
NOT azithromycin |
| |
Fluoxetine |
|
Cimetidine |
| |
Haloperidol |
|
Clarithromycin |
| |
Methadone |
|
Diltiazem |
| |
Mibefradil |
|
Erythromycin |
| |
Paroxetine |
|
Fluvoxamine |
| |
Quinidine |
|
Itraconazole |
| |
Ritonavir |
|
Ketoconazole |
| |
Doxepin |
|
Mibefradil |
| |
|
|
Nefazodone |
| |
|
|
Troleandomycin |
| |
|
|
Verapamil |
|
INDUCERS | |||
|
1A2 |
2B6 |
2C8 |
2C19 |
| N/A |
Phenobarbital |
N/A |
N/A |
| |
Phenytoin |
|
|
| |
Rifampin |
|
|
|
2C9 |
2D6 |
2E1 |
3A4,5,7 |
| Rifampin |
N/A |
Isoniazid |
Carbamazepine |
| Secobarbital |
|
|
Phenobarbital |
| |
|
|
Phenytoin |
| |
|
|
Pioglitazone |
| |
|
|
Rifabutin |
| |
|
|
Rifampin |
| |
|
|
St John’s wort |
| Troglitazone | |||
(Adapted with permission from Version 5.0 (http://medicine.iupui.edu/clinpharm/ddis/table.aspx)).
1A2, 2B6 etc = CYP enzyme subtypes.