Figure 4.
Possible strategies for NADPH oxidase inhibition. Several steps that can be used to modulate NADPH oxidase activity. (1) NADPH oxidase subunits expression. (2) Signaling upstream of NADPH oxidase activation. (3) Association of cytosolic subunits and formation of the complete enzyme complex. (4) Subunit phosphorylation (P) and activation. (5) Modulation of cytosolic calcium concentration. (6) Transference of electrons through the enzyme complex.
Abbreviations: Ca2+, calcium ion; CaM, calmodulin; e−, electron; FAD, flavin adenine dinucleotide; HSP90, heat shock protein 90; NADPH, nicotinamide adenine dinucleotide phosphate; O2−, superoxide anion; O2, oxygen.