Table II.
Baseline biomarkers of participants with and without PAD
| Overall (N = 959) | Subjects with PAD (n = 172) |
Subjects without PAD (n = 787) |
P | |
|---|---|---|---|---|
| Baseline lipid and HbA1c values* | ||||
| Total cholesterol (mg/dL) | 142 ± 28 | 142 ± 31 | 142 ± 28 | .8373 |
| LDL-C (mg/dL) | 67 ± 22 | 67 ± 22 | 68 ± 21 | .6846 |
| HDL-C (mg/dL) | 50 ± 13 | 50 ± 14 | 50 ± 13 | .7620 |
| Triglycerides (mg/dL) | 127 ± 65 | 132 ± 76 | 126 ± 63 | .1760 |
| HbA1c (%) | 6.7 ± 1.04 | 6.5 ± 0.97 | 6.7 ± 1.05 | .0535 |
| Baseline Inflammatory biomarker values† | ||||
| Lp-PLA2 activity (nmol min−1 mL−1) | 123 (107, 145) | 125 (109, 149) | 123 (107, 145) | .3056 |
| hs-CRP (mg/L) | 1.17 (0.6, 2.5) | 1.32 (0.6, 2.6) | 1.14 (0.6, 2.4) | .1252 |
| IL-6 (ng/L) | 2.53 (1.7, 3.5) | 2.88 (2.0, 4.2) | 2.46 (1.7, 3.3) | .0035 |
| Myeloperoxidase (pmol/L) | 556 (380, 755) | 600 (422, 826) | 547 (375, 743) | .0660 |
| Matrix metalloproteinase-9 (µg/L) | 499 (273, 877) | 593 (323, 1050) | 481 (260, 830) | .0017 |
| Adiponectin (ng/mL) | 6.73 (4.2, 10.6) | 7.9 (4.9, 13.1) | 6.5 (4.2, 10.2) | .0017 |
| ICAM-1 (µg/L) | 262 (224, 300) | 280 (235, 327) | 259 (222, 295) | .0011 |
| Osteoprotegerin (pmol/L) | 577 (4.7, 7.0) | 6.17 (5.0, 7.0) | 5.69 (4.6, 7.0) | .0046 |
| Baseline platelet biomarker values† | ||||
| P-selectin (µg/L) | 49 (38, 62) | 50 (39, 63) | 49 (37, 61) | .3631 |
| CD40L (pg/mL) | 375 (188, 669) | 411 (216, 707) | 367 (181, 654) | .1511 |
| U-11-dehydro-TxB2 (ng/mmol Cr) | 56 (35, 81) | 58 (35, 88) | 55 (34, 80) | .3657 |
HbA1c, Hemoglobin A1c; TxB2, thromboxane B2.
*
Presented as arithmetic mean ± SD.
†
Presented as geometric mean (interquartile range: 25th, 75th percentile).