Table 2.
Mean (SD) regional deposition and clearance indices of inhaled aerosol at 4 hours post challenge (PC) compared to baseline (Base) for responders (late phase (LPR) and non-late phase (nLPR)) and non-responders.
| Skew | C/P | 24 hr clear (%) | Central TB Ave120Ret |
|||||
|---|---|---|---|---|---|---|---|---|
| Base | PC | Base | PC | Base | PC | Base | PC | |
| Responders (n=9) | 2.00 (0.45) | 2.53* (0.78) | 1.85 (0.43) | 2.20 (0.61) | 52 (16) | 66* (12) | 0.69 (0.17) | 0.79 (0.22) |
| nLPR (n=6) | 2.17 (0.32) | 2.64 (0.68) | 2.17 (0.32) | 2.32 (0.72) | 59 (12) | 66 (14) | 0.71 (0.17) | 0.74 (0.20) |
| LPR (n=3) | 1.67 (0.54) | 2.31 (1.10) | 1.50 (0.36) | 1.97 (0.28) | 38 (12) | 66 (10) | 0.67 (0.22) | 0.88 (0.25) |
| Non-responders (n=3) | 1.75 (0.60) | 1.65 (0.65) | 2.01 (0.82) | 2.11 (1.13) | 43 (6) | 41 (13) | 0.77 (0.20) | 0.69 (0.25) |
P ≤ 0.02 compared to baseline.