Fig. 2.

Whole body net glucose (A) and amino acid (B) disposal rates during pancreatic glucose-amino acid clamp in control and pST-treated pigs. Pigs were infused with insulin at 18, 90, and 200 ng·kg^−0.66·min⁻¹ to reproduce fasting (5 μU/ml), fed control (25 μU/ml), or fed pST-treated (50 μU/ml) levels, while glucose and amino acids were clamped at baseline fasting levels. Glucose disposal rates were calculated from the average rate of infusion of a dextrose solution over the last hour of infusion. Amino acid disposal rates were calculated from the average rate of infusion of a balanced amino acid solution required for maintenance of circulating BCAA at baseline fasting levels over the last hour of infusion. ANOVA indicated an insulin effect (P < 0.001) for both glucose and amino acid uptakes. Results of paired t-test: †response to insulin dose different from fasting (5 μU/ml, P < 0.05). Values are means ± SE; n = 5–7 per group.