Fig. 6.
Association of the 4E-BP1·eIF4E (A) and eIF4G·eIF4E (B) complexes in skeletal muscle at the end of a pancreatic glucose-amino acid clamp in control and pST-treated pigs. Pigs were infused with insulin at 18, 90, and 200 ng·kg−0.66·min−1 to reproduce fasting (5 μU/ml), fed control (25 μU/ml), or fed pST-treated (50 μU/ml) levels, while glucose and amino acids were clamped at baseline fasting levels. ANOVA indicated an effect of insulin (P < 0.001) for both complexes. Results of paired t-test: †response to insulin dose different from fasting (5 μU/ml, P < 0.05). Values are means ± SE; n = 5–7 per group.