Table 3.
Real-time quantitative PCR validation of MACS-identified genes differentially acetylated for H4K5 in FC over control in the hippocampus [HIP] and cerebellum [CER]
| Gene ID | Gene name | Fold-change [HIP]* | Significance [HIP] | Fold-change [CER] | Significance [CER] |
|---|---|---|---|---|---|
|
Fbxl11 |
F-box and leucine-rich repeat protein 11 [Lysine (K)-specific demethylase 2A (Kdm2a)] |
4.31±1.40 |
0.05 |
1.04±0.05 |
NS |
|
Ryr3 |
Ryanodine receptor 3 |
3.92±1.70 |
0.1 |
1.10±0.51 |
NS |
|
Akap6 |
A kinase (PRKA) anchor protein 6 |
3.77±0.71 |
0.01 |
3.94±1.37 |
0.05 |
|
Atp8a1 |
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 |
3.35±0.46 |
0.01 |
0.96±0.23 |
NS |
|
Nrxn1 |
Neurexin I |
2.99±0.29 |
0.001 |
1.21±0.58 |
NS |
|
Rnf220 |
Ring finger protein 220 |
2.98±1.84 |
NS |
1.30±0.53 |
NS |
|
Kcnd2 |
Potassium voltage-gated channel, Shal-related family, member 2 |
2.94±0.36 |
0.001 |
0.46±0.11 |
NS |
|
Grid1 |
Glutamate receptor, ionotropic, delta 1 |
2.92±0.60 |
0.05 |
1.15±0.33 |
NS |
|
Col2a1 |
Collagen, type II, alpha 1 |
2.35±0.42 |
0.01 |
1.01±0.21 |
NS |
|
Serpina9 |
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 |
1.90±0.90 |
NS |
0.82±0.40 |
NS |
|
Megf11 |
Multiple EGF-like-domains 11 |
1.71±0.67 |
NS |
1.01±0.33 |
NS |
| Ntrk2 | Neurotrophic tyrosine kinase, receptor, type 2 | 1.09±0.15 | NS | 1.32±0.20 | NS |
* Ranked according to fold-change in HIP.
Shown as fold-change over control ± SEM.
NS not significant.