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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Inflamm Bowel Dis. 2012 Jan 24;18(9):1735–1742. doi: 10.1002/ibd.22878

FIGURE 1.

FIGURE 1

PKR−/− mice are more sensitive to DSS-induced colitis. PKR−/− and PKR+/+,+/− littermates were reconstituted with wildtype bone marrow cells. After 8 weeks the mice were fed 3% DSS in drinking water for 7 days; their body weight and rectal bleeding were monitored daily. (A) Colonic epithelial cells isolated from PKR−/− mice after bone marrow transplantation show very low levels of Pkr mRNA. (B) PKR−/− mice show more significant body weight loss during DSS colitis. (C) PKR−/− mice show more severe rectal bleeding during DSS colitis. (D) PKR−/− mice show more severe colon shortening after 7-day of DSS administration. PKR+/+,+/− : n = 13; PKR−/− : n = 11; *P < 0.05, **P < 0.01. (E) Two-month-old C57BL/6J wildtype mice were reconstituted with PKR+/+ or PKR−/− bone marrow cells. After 8 weeks the mice were fed 3% DSS in drinking water for 5 days followed by 2 days of free water; their body weight was monitored daily. PKR+/+ : n = 8; PKR−/−: n = 7.