Figure 1.

TNFa inhibit cholesterol efflux from human macrophages. After human macrophages were labeled with 3H-cholesterol, the indicated doses of either TNFa or the vehicle were added to the cultures, which were then incubated in the presence of either 10 μg/mL human apoA-I (A) or 50 μg/mL of human HDL (B) for 24 h. Cholesterol efflux was determined as described in Methods. Data are presented as mean ± SEM, *P < 0.05 vs control.