Table 1.
Demographic and other baseline characteristicsa
| Parameter | Group 1: healthy (n = 6) | Group 2: mild (n = 6) | Group 3: moderate (n = 6) | Group 4: severe (n = 6) | All (n = 24) |
|---|---|---|---|---|---|
| Age (years) [mean ± SD] | 65.7 ± 1.9 | 71.2 ± 5.4 | 71.3 ± 4.6 | 65.0 ± 14.6 | 68.3 ± 8.2 |
| Height (cm) [mean ± SD] | 165.6 ± 3.7 | 166.0 ± 8.7 | 170.3 ± 9.1 | 163.5 ± 10.4 | 166.4 ± 8.2 |
| Bodyweight (kg) [mean ± SD] | 74.2 ± 3.5 | 69.8 ± 9.8 | 79.3 ± 12.9 | 68.6 ± 12.4 | 72.9 ± 10.6 |
| Sex (n) | |||||
| Male | 5 | 5 | 5 | 4 | 19 |
| Female | 1 | 1 | 1 | 2 | 5 |
| GFR (mL/min/1.73 m2) [mean ± SD] | 110.0 ± 13.1 | 63.3 ± 7.8 | 38.5 ± 6.8 | 20.0 ± 6.7 | |
| Concomitant medications | |||||
| Number of subjects | 0 | 2 | 3 | 4 | 9 |
| Angiotensin II antagonists | 0 | 0 | 0 | 3 | 3 |
| Angiotensin II antagonists + diuretics | 0 | 0 | 1 | 0 | 1 |
| ACE inhibitors | 0 | 1 | 0 | 0 | 1 |
| β-Blocking agents | 0 | 1 | 0 | 0 | 1 |
| Amlodipine | 0 | 1 | 0 | 0 | 1 |
| Furosemide | 0 | 0 | 1 | 0 | 1 |
| Tamsulosin | 0 | 1 | 0 | 0 | 1 |
| Clopidogrel | 0 | 0 | 1 | 0 | 1 |
| Allopurinol | 0 | 0 | 0 | 1 | 1 |
| Metformin | 0 | 1 | 2 | 0 | 3 |
| Insulin | 0 | 0 | 1 | 1 | 2 |
| Alprazolam | 0 | 0 | 0 | 1 | 1 |
| Chlordiazepoxide/clidinium | 0 | 0 | 0 | 1 | 1 |
aGroups categorized according to degree of renal impairment
GFR glomerular filtration rate, SD standard deviation