Table 4.

Analysis of variance of pharmacokinetic parameters^a

Group	PK parameter	Geometric LS means		Geometric mean ratiob	90 % CIc
		Test group	Reference (group 1: healthy)
2: Mild	AUC∞	958.8	703.3	1.36	0.94–1.97
	AUClast	937.0	698.6	1.34	0.93–1.94
	Cmax	167.0	134.6	1.24	0.89–1.72
	t max d	1.50	1.50	0.00
3: Moderate	AUC∞	1,363.9	703.3	1.94	1.34–2.81
	AUClast	1,358.0	698.6	1.94	1.35–2.81
	Cmax	269.7	134.6	2.00	1.45–2.78
	tmax d	2.25	1.50	0.75
4: Severe	AUC∞	1,513.9	703.3	2.15	1.49–3.12
	AUClast	1,472.3	698.6	2.11	1.46–3.04
	Cmax	214.0	134.6	1.59	1.15–2.20
	tmax d	1.50	1.50	0.00

^aGroups categorized according to degree of renal impairment

^bRatio of geometric means of test and control groups

^cA 90 % CI that falls within the interval 0.8–1.25 leads to the conclusion that the two groups are bioequivalent

^dThe median values in the first two columns and the difference of median values in the column of geometric mean ratio are presented, respectively

AUC, area under plasma concentration–time curve; AUC_last, AUC from time zero to time of last measurable plasma concentration; AUC_∞, AUC from time zero to infinity; C_max, maximum plasma concentration; LS, least squares; PK, pharmacokinetic; t_max, time to reach C_max