Table 1.
Indicators of the Effects of Ethanolic Extract of Adenocaulon himalaicum and Its Fractions in Hepa1c1c7 and HCT116 Cells
| |
Hepa1c1c7 |
HCT116 |
||
|---|---|---|---|---|
| CD (μg/mL) | IC50 (μg/mL) | CI | IC50 (μg/mL) | |
| AHE | 19.1 | 197.7 | 10.4 | 151.7 |
| Hexane fraction | 17.5 | 102.2 | 5.8 | 73.2 |
| Ethyl acetate fraction | 24.7 | >200.0a | 8.1 | >200.0a |
| AHB | 14.3 | 177.0 | 12.4 | 134.5 |
| Water fraction | 27.7 | 106.6 | 3.8 | 136.7 |
| Sulforaphane (μM) | 1.17 | 14.96 | 12.8 | |
a
The highest limit of test concentration was 200 μg/mL. If the extract had no cytotoxicity, 200 μg/mL was used to calculate the CI value.
CD, concentration required to double QR activity; IC50 concentration required to inhibit cell growth by 50%; CI (chemoprevention index)=IC50/CD; AHE, ethanolic extract of Adenocaulon himalaicum; AHB, butanolic fraction of AHE; QR, quinone reductase.