Figure 3.

Correlation analysis of KREC quantification with B-cell subset recovery after alloHSCT. (A,C,E) Absolute CD19⁺ B-cell subset counts of IgD⁺CD27^-CD38^hi transitional B, IgD⁺CD27^-CD38^int naïve B and CD27⁺ memory B cells and KREC copy number were determined before and after transplantation (preTx: n=7, D15 n=11, D30 n=13, D60 n=8, D90 n=12, D180 n =9). KREC copy number per ml blood (grey line, A,C,E) and absolute number of transitional (A), naïve (C) and memory B cells (E) per ml blood (black line) are shown as mean values ± SEM. (B,D,F) Absolute KREC copy number and B-cell subset count are depicted as scatterplots with linear regression line for transitional (B), naïve (D) and memory B cells (F). The regression coefficients beta (β*) and p-values are displayed for each subpopulation.