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. 2001 Jul 3;98(15):8786–8791. doi: 10.1073/pnas.151247498

Figure 3.

Figure 3

Schematic pattern of the interaction of TAT peptide-containing liposomes with cell surface: LIP-NGPE-TAT (TAT peptide is located directly on the surface of liposome) (A), LIP-pNP-PEG(3000)-TAT (TAT peptide is coupled via PEG spacer) (B), LIP-PEG(2000)/pNP-PEG(3000)-TAT (TAT peptide is attached to PEGylated liposomes; the length of protecting PEG is smaller that the length of PEG spacer) (C), and LIP-PEG(5000)/pNP-PEG(3000)-TAT (TAT peptide is attached to PEGylated liposomes; the length of protecting PEG is bigger that the length of PEG spacer) (D). 1, phospholipid constituting liposomes; 2, PE anchor for TAT peptide or TAT peptide-bearing PEG spacer; 3, TAT peptide; 4, PEG chains of variable length; and 5, hypothetical sites of TAT peptide interaction with the cell surface.