. 2013 Jul;11(6):382–387. doi: 10.1089/adt.2013.514

Table 2.

Inhibition of Cholera Toxin Expression by Exogenous Cyclic Adenosine Monophosphate Receptor Protein Ligands

Effect of Genetic Mutations		Effect of Exogenous CRP Ligands
Culture	Cholera toxin (μg/mL/OD₆₀₀)^a	Culture	Cholera toxin (μg/mL/OD₆₀₀)^a	% Inhibition
C7258	2.54±0.14	C7258+cAMP	0.86±0.05	66^b
C7258Δcrp	6.41±0.76	C7258+7-deaza-cAMP	0.56±0.06	78^b
C7258Δcya	10.52±0.12	C7258Δcya+cAMP	2.87±0.44	73^c
C7258crp^*	0.64±0.02	C7258Δcya+7-deaza-cAMP	2.06±0.26	80^c
C7258Δcya crp^*	0.64±0.03

^aEach value is the mean of at least three independent cultures.

^bInhibition relative to strain C7258.

^cInhibition relative to C7258Δcya. Final concentrations for cAMP and 7-deaza-cAMP were 50 μM.

cAMP, cyclic adenosine monophosphate; CRP, cAMP receptor protein.