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Pazopanib inhibits tumor growth in a xenograft orthotopic model of CDDP-primary refractory yolk sac testicular germ cell tumor. Mice with an orthotopically implanted TGT44 CDDP-refractory yolk sac tumor were treated with vehicle, four injections of 4 mg/kg CDDP or daily 100 mg/kg pazopanib for six weeks. Mice were sacrificed when control mouse tumors affected the wellbeing of the animals. Final volumes are illustrated by a boxplot. *, p < 0.05 (two-tail Mann–Whitney U test).
