Figure 1.

Cross producing the eight genotypes of the SCT model (A) and project timeline (B). All mice were outbred MF1 strain. We attempt to maintain genetic diversity in our colony, but the X chromosomes of all mice used here were identical and derived originally from mating an XY mouse with his XO dam to produce a line of mice with identical X chromosomes bred onto outbred stock (P Burgoyne, personal communication). Thus, in these experiments, differences between mice with one vs. two X chromosomes were attributable to the number of X chromosomes, not to a difference in X alleles.