Table 4.
Effects for workplace ETS exposure (n/y), the SNPs, and the interaction of GSTO SNPs (recessive model) with workplace ETS exposure on FEV1
| FEV1 (ml) b (95% CI) | ||||
|---|---|---|---|---|
|
Gene |
Variable |
All |
Never smokers |
Ever smokers |
| |
N, in analysis |
7149 |
3051 |
4098 |
|
GSTO1 |
Workplace ETS |
−26 (−71 ; 20) |
−51 (−126 ; 25) |
−17 (−73 ; 40) |
| |
rs4925 |
8 (−34 ; 50) |
78 (17 ; 138) |
−48 (−105 ; 9) |
| |
ETS*rs4925 |
$-173 (−313 ; -33)* |
$-281 (−498 ; -64)* |
−84 (−268 ; 100) |
|
GSTO1 |
Workplace ETS |
−22 (−68 ; 25) |
−41 (−117 ; 36) |
−15 (−73 ; 43) |
| |
rs1147611 |
8 (−27 ; 42) |
49 (0 ; 99)# |
−29 (−78 ; 19) |
| |
ETS*rs1147611 |
$-151 (−272 ; -31)* |
$-286 (−486 ; -87)** |
−65 (−218 ; 87) |
|
GSTO2 |
Workplace ETS |
−21 (−67 ; 25) |
−41 (−118 ; 36) |
−14 (−72 ; 44) |
| |
rs156697 |
8 (−28 ; 44) |
50 (−1 ; 100) |
−29 (−79 ; 20) |
| |
ETS*rs156697 |
$-170 (−295 ; -46)** |
$-287 (−486 ; -88)** |
−84 (−245 ; 77) |
|
GSTO2 |
Workplace ETS |
−17 (−63 ; 28) |
−41 (−117 ; 35) |
−9 (−66 ; 48) |
| |
rs156699 |
6 (−32 ; 45) |
43 (−12 ; 98) |
−26 (−79 ; 28) |
| ETS*rs156699 | $-218 (−349 ; -87)** | $-318 (−525;-111)** | −140 (−311 ; 30) | |
The linear regression model for the whole group was adjusted for sex, age, height, weight, current, ex-smoking and packyears smoked. Consequently we stratified by smoking status (never/ever) and adjusted for the other possible confounders.
*p-value<0.05 **p-value<0.01.
$significant after FDR correction for multiple testing.