Table 5.
Verification of the interaction of GSTO SNPs (recessive model) with different types of ETS exposure on FEV1 in sample 2
| FEV1 (ml) b (95% CI) | ||||
|---|---|---|---|---|
|
Gene |
Variable |
In utero ETS |
Daily ETS |
Workplace ETS |
| |
N, in analysis |
3914 |
4527 |
4702 |
|
GSTO1 |
ETS |
−45 (−91 ; 1) |
−41 (−78 ; -4)* |
−40 (−98 ; 18) |
| |
rs4925 |
11 (−43 ; 65) |
15 (−36 ; 66) |
33 (−17 ; 83) |
| |
ETS*rs4925 |
111 (−32 ; 253) |
25 (−93 ; 142) |
−163 (−390 ; 65) |
|
GSTO1 |
ETS |
−49 (−96 ; -1)* |
−40 (−78 ; -2)* |
−40 (−100 ; 20) |
| |
rs1147611 |
4 (−40 ; 47) |
21 (−21 ; 63) |
26 (−15 ; 67) |
| |
ETS*rs1147611 |
94 (−22 ; 211) |
5 (−89 ; 98) |
−87 (−254 ; 81) |
|
GSTO2 |
ETS |
−52 (−99 ; -5)* |
−41 (−79 ; -4)* |
−38 (−98 ; 21) |
| |
rs156697 |
2 (−42 ; 46) |
17 (−25 ; 59) |
28 (−13 ; 69) |
| |
ETS*rs156697 |
119 (0 ; 237)* |
17 (−79 ; 113) |
−99 (−269 ; 70) |
|
GSTO2 |
ETS |
−46 (−92 ; 1) |
−40 (−78 ; -3)* |
−42 (−101 ; 17) |
| |
rs156699 |
−9 (−58 ; 39) |
0 (−46 ; 47) |
10 (−35 ; 56) |
| ETS*rs156699 | 106 (−29 ; 241) | 9 (−97 ; 115) | −101 (−292 ; 91) | |
Effects for in utero ETS exposure (no/yes), daily ETS exposure (</≥1 hr), workplace ETS exposure (no/yes), the SNPs, and the interaction of GSTO SNPs (recessive model) with different types of ETS exposure on FEV1 in sample 2 (verification). The linear regression model for the whole group was adjusted for sex, age, height, weight, current, ex-smoking and packyears smoked.
*p-value<0.05.