Figure 2.

Plasma aldosterone and renin levels in kcne1^−/− and wild-type mice challenged with various K⁺ or Na⁺ diets. The dosages were performed on blood collected from animals maintained on a normal diet or fed high or low K⁺ diets or a low Na⁺ diet for 2 weeks. (A) The hyperaldosteronism in kcne1^−/− mice is blunted by low K⁺ or Na⁺ diets but strongly exacerbated by high K⁺ intake. (B) PRC is not different between kcne1^−/− and wild-type mice except on the high K⁺ diet, which does not decrease PRC in kcne1^−/− mice. PRC is expressed as the amount of angiotensin I formed per ml of plasma per h of incubation.