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Picture depicting the two regions of the H1N1 neuraminidase binding site. The red region (A) is the electronegative region, where the amine-rich functional groups of ligands bind, and the large blue region (B) a large electropositive zone. The deep binding pocket (A) could host many kinds of ligands, but high affinity can be obtained only when there is a well defined functional group interaction (electrostatic and/or structural).
