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KN-93 had no antiparkinsonian effect on PD rats. Levodopa treatment decreased apomorphine-induced rotations in PD rats on day 22 compared to day 1.
Notes: There was no significance in apomorphine-induced rotations between rats treated with vehicle and different dose of KN-93. Data are presented as mean ± standard error of the mean (error bars). *P < 0.01, compared to day 1.
Abbreviation: PD, Parkinson’s disease.
