Table 3.

Multivariate analysis of association between on-treatment neutropenia and OS for non-small cell lung cancer and ovarian cancer

Tumour type	HR for death (95% CI)	P-value
NSCLC
Neutropenia grade 0	1.6 (1.02;2.65)	0.04
Baseline neutrophils ≥ 4.5	2.0 (1.11;3.44)	0.02
Stage IV cancer	1.8 (1.18;2.71)	0.006
Relative chemo intensity < 100%	1.7 (1.11;2.60)	0.01
Ovarian cancer
Neutropenia grade 0	1.7 (1.04;2.93)	0.04
Residual disease > 1 cm	2.9 (1.73;4.81)	0.0001
Age at diagnosis	1.02 (1.00;1.05)	0.04
Ascites present	2.2 (1.11;4.23)	0.02
CA125 not normalized	3.2 (1.75;6.00)	0.0001

Factors with multivariate significance level <0.05 are shown.

Abbreviations: OS overall survival; NSCLC Non-Small Cell Lung Cancer; Grade 0 neutropenia at nadir ≥ 2.0 × 10^9/L; CA125 Cancer antigen 125.