Table 1.
Neural activation decrease over time in the phobic group
| Structure | H | x | y | z | Zmax | pfwe |
|---|---|---|---|---|---|---|
|
Phobia gt neutral |
|
|
|
|
|
|
| Middle temporal gyrus |
L |
−45 |
14 |
−29 |
4.92 |
.029E |
| insula |
L |
−30 |
20 |
−8 |
3.30 |
.069+ |
| caudate nucleus |
R |
21 |
−16 |
22 |
3.45 |
.037 |
| dlPFC |
L |
−24 |
32 |
46 |
3.74 |
.071+ |
| dmPFC |
L |
−6 |
29 |
40 |
4.79 |
.001 |
| .050E+ | ||||||
| dmPFC |
L |
−3 |
53 |
7 |
3.99 |
.017 |
| dmPFC |
R |
6 |
47 |
4 |
4.33 |
.004 |
| dmPFC |
R |
6 |
32 |
43 |
3.33 |
.098+ |
| rACC |
L |
−3 |
50 |
7 |
4.00 |
.006 |
| rACC |
R |
6 |
44 |
4 |
3.87 |
.009 |
| vlPFC |
L |
−39 |
29 |
13 |
4.14 |
.011 |
| vlPFC |
L |
−45 |
17 |
13 |
3.57 |
.071+ |
| vmPFC |
L |
−3 |
56 |
−11 |
4.05 |
.008 |
| vmPFC |
R |
9 |
59 |
−14 |
3.76 |
.021 |
|
Neutral gt phobia |
|
|
|
|
|
|
|
no significant results |
|
|
|
|
|
|
|
Phobia gt fear |
|
|
|
|
|
|
| insula |
L |
−39 |
−1 |
4 |
3.18 |
.097+ |
| vlPFC |
L |
−45 |
8 |
10 |
3.94 |
.023 |
| vlPFC |
R |
48 |
17 |
1 |
3.57 |
.076+ |
|
Fear gt phobia |
|
|
|
|
|
|
|
no significant results |
|
|
|
|
|
|
|
Phobia gt disgust |
|
|
|
|
|
|
| rACC |
R |
6 |
38 |
13 |
3.94 |
.031 |
|
Disgust gt phobia |
|
|
|
|
|
|
| vmPFC |
R |
9 |
29 |
−23 |
3.57 |
.034 |
| vmPFC | R | 3 | 23 | −23 | 3.52 | .039 |
Neural activation decrease over the course of symptom provocation for phobic compared with neutral pictures for exploratory whole brain analyses (marked with E) and regions of interest analyses (pfwe < .05); tendentially significant results pfwe < .1 are marked with +; all coordinates (x, y, z) are given in MNI space. H, hemisphere; L, left R, right; Zmax, maximum Z-value pfwe, fwe-corrected p-value (small-volume correction).